Methandroplex 20 is an oral steroid known for its significant impact on protein metabolism. As a testosterone derivative, it exhibits potent anabolic and androgenic characteristics. Its influence on protein metabolism enhances protein synthesis, resulting in a positive nitrogen balance that fosters protein accumulation and, consequently, an increase in skeletal muscle mass. Additionally, Methandroplex 20 contributes to an enhanced sense of well-being.
Recognized as one of the most effective mass-building steroids ever developed, Methandroplex 20 was specifically designed for athletes aiming to enhance their performance, although it was also claimed to have therapeutic uses. Most users experience remarkable gains in weight and strength, with increments of 3-4 pounds per week being common, especially among beginners. It is important to note that a significant portion of this weight is water retention, and higher dosages may lead to side effects such as gynecomastia, elevated blood pressure, and acne. When taken orally, Methandienone acts quickly but typically remains effective for less than half a day; hence, it is often recommended to distribute dosages throughout the day.
Research indicates that a dosage of 20 mg of Methandroplex 20 is sufficient for full androgen replacement in men, elevating androgen anabolic activity by approximately five times above normal and achieving a reduction in natural cortisol levels by 50-70%. Nevertheless, many athletes opt for daily intakes of 50-100 mg, although exceeding 50 mg per day may result in diminishing returns.
However, Methandroplex 20 does have negative side effects associated with its overuse, particularly concerning liver function. Fortunately, these effects are typically temporary, and liver values usually normalize. Other side effects include estrogenic symptoms, which can be mitigated by combining Methandienone with an anti-estrogen. Potential side effects may consist of gynecomastia, salt and water retention, high blood pressure, oily skin, facial hair growth, and mild acne. Due to the moderate androgenic properties of Methandroplex 20, high doses might also cause some degree of male-pattern hair loss. Additionally, users may experience changes in mood, such as increased aggression, irritability, or, conversely, depression.
Most of these effects are believed to be independent of androgen receptor mediation, attributable to Methandroplex 20's low affinity for androgen receptors, which also illustrates its minimal aromatase activity. Users of Methandienone need not be concerned about a sudden drop in their natural testosterone levels as the side effects are not primarily linked to androgen receptor activity.
Since Methandroplex 20 readily aromatizes, it may not be the best choice for those training for competitions. However, it is a standout option among oral steroids for individuals aiming for significant size increases. Methandienone has a half-life of only 3.2 - 4.5 hours, suggesting that it should be taken twice daily to maintain substantial levels in the bloodstream.